Abstract Genome editing using CRISPR-Cas systems is a promising avenue for the treatment of genetic diseases.However, cellular Kidney Formulas and humoral immunogenicity of genome editing tools, which originate from bacteria, complicates their clinical use.Here we report reduced immunogenicity (Red)(i)-variants of two clinically relevant nucleases,
Romania has the largest number of EU holdings.For this purpose, this paper analyses the effect of the excessive agricultural land fragmentation caused by the laws and measures adopted in the previous period.The existence of small holdings is influenced by the land property structures and at the same time, by the training and experience level of hol
Alternative procedures to the judicial way existed in the Roman Law to solve controversies; many of them emerged in the family environment and in the business world.At present, through Mediation, Negotiation and Arbitration (Alternative Dispute Resolution - ADR), more favorable agreements can be obtained for the interests of both parties.In additio
Sinus of Valsalva aneurysm is a rare congenital disorder that usually presents with rupture of the aneurysm into adjacent cardiac structures.It usually arises from the right sinus of Valsalva which ruptures into the right ventricle or right atrium (RA).Aneurysms may also arise from the noncoronary cusp that rupture into RA.Rarely, an unruptured ane
Pod dehiscence or pod shattering from mature soybean (Glycine max L.) is one of the most outstanding disadvantages in domesticated cultivars.Pod shattering in relation to 16 quantitative traits and 3 qualitative traits among 140 cultivars of BURGUNDY PWD vegetable soybeans, grain soybeans and small-grain soybeans was evaluated over two years.We fou